Factors affecting clinical outcomes post-lower limb bypass
Research type
Research Study
Full title
Investigating the role of education and socioeconomic status on clinical outcomes following lower-limb bypass surgery
IRAS ID
201693
Contact name
Abigail Morbi
Contact email
Sponsor organisation
Imperial College
Duration of Study in the UK
0 years, 3 months, 30 days
Research summary
Peripheral arterial disease is reported to affect 16.9% men and 20.5% women aged 55 and above (Rotterdam Study). The most severe presentation of peripheral arterial disease is critical limb ischaemia, which not only affects patients' daily activities and quality of life, but can result in limb-loss and mortality. Patients are referred to a vascular surgeon, for investigation and consideration of surgery or minimally-invasive interventions (angioplasty and stenting) to prevent limb loss. Intervention is not without risk and some patients will have poor outcomes, requiring further intervention and/or amputation. Patients with peripheral arterial disease are at risk of cardiovascular complications, such as heart attack and stroke, due to having risk factors such as high blood pressure, high cholesterol and smoking. We need to look at ways to improve management of risk factors, to reduce cardiovascular complications, and need to identify and target factors that affect outcomes following surgery, to improve long-term clinical outcomes.
This 3-month study aims to identify factors affecting clinical outcomes after lower-limb bypass surgery. A database of all patients who underwent lower-limb bypass at St. Mary's Hospital, a tertiary referral centre, between 2005 and 2010 will be created. Data collected from patient notes and electronic records will include patient demographics (such as age, gender, smoking status, other medical conditions) and post-surgical outcomes, including the need for further surgery, amputation, any complications and deaths within 5 years of surgery. There is evidence that socioeconomic status affects outcomes and patient education and self-management are important in managing risk factors and chronic disease. Patients will therefore be contacted by telephone to ascertain socioeconomic status, level of education and adherence to risk factor management. Exclusion criteria: patients unable to give consent. Statistical analysis will identify which factors significantly affect outcomes and results may inform the design of interventions to improve care.
REC name
North West - Liverpool Central Research Ethics Committee
REC reference
16/NW/0178
Date of REC Opinion
8 Mar 2016
REC opinion
Favourable Opinion