Facial and Oral Phenotypes for Genetic studies Version 1
Research type
Research Study
Full title
Three-dimensional facial and dental phenotypes in malocclusion and it’s genetic perspectives.
IRAS ID
273456
Contact name
Peter Mossey
Contact email
Sponsor organisation
University of Dundee
Duration of Study in the UK
1 years, 6 months, 24 days
Research summary
Generation Scotland (GS) is a resource of genetic, health and lifestyle data obtained from healthy adult volunteers across Scotland. The aim of GS is to create population-based data, which researchers could utilise to improve the understanding of the underlying genetic basis of complex conditions, including facial and dental features which will add to invaluable research resource that has already been collected for more than 20000 Scottish participants. This project aims to fill the gap of missing data by recontact of GS participants to capture their facial and dental images by using cutting-edge 3D technology.
This is a pilot study where we anticipate recruiting 200 unrelated adults from GS cohort. First, we will have a pre-run of 50 to evaluate how we handle the recruitment process and to estimate the response rate. Therefore, we would be able to calculate the expected sample size. All participants will be asked to complete a study survey via phone or online. Then, they will be invited to have their 3D facial and intra-oral images recorded in Dundee or Glasgow dental hospital as well as completing two short tablet computer delivered or paper-based questionnaires.
We will use an intraoral video camera and 3D facial camera for collecting the images and the data will be segregated into different groups based on their facial and dental features (described as phenotype). And finally, we will correlate different facial and dental features to different genetic variants (phenotype genotype correlation).
This pilot study will provide 3D tools necessary to undertake a larger study in the future to identify and measure the complex relationships between genetics and specific oral and facial phenotypes of malocclusion. Understanding of the genetic basis of dentofacial variations is fundamental for developing diagnostic, prognostic and treatment strategies for individual patients.REC name
South East Scotland REC 01
REC reference
20/SS/0029
Date of REC Opinion
30 Apr 2020
REC opinion
Further Information Favourable Opinion