Eye assessments in traumatic brain injury
Research type
Research Study
Full title
Assessment of ophthalmic structure and function in traumatic brain injury
IRAS ID
280424
Contact name
Richard Blanch
Contact email
Sponsor organisation
University of Birmingham
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
1 years, 6 months, 1 days
Research summary
Traumatic brain injury (TBI) is defined as an alteration to brain function or other evidence of brain pathology, caused by an external force. It is a major cause of morbidity and mortality worldwide. One effect of TBI is optic nerve damage, otherwise known as traumatic optic neuropathy (TON), which may cause blinding visual loss.
Diagnosis of TON may be delayed where the patient has other life-threatening injuries and clinical diagnosis maybe challenging during the early presentation of acutely injured patients. The use of optical coherent tomography (OCT) is beneficial in assessing and monitoring changes in the optic nerve and retina, whilst other standard visual function tests evaluate residual visual function and allow correlation with the structure of the optic nerve and retina examined by OCT.
We intend to use OCT to examine in detail early structural changes in the retina and optic nerve associated with traumatic optic neuropathy.REC name
West Midlands - Coventry & Warwickshire Research Ethics Committee
REC reference
20/WM/0178
Date of REC Opinion
26 Jun 2020
REC opinion
Further Information Favourable Opinion