EXTRACELLULAR VESICLES IN STROKE
Research type
Research Study
Full title
A STUDY OF THE PREDICTIVE NATURE OF EXTRACELLULAR VESICLES IN A TRANSIENT ISCHAEMIC ATTACK PATIENT COHORT
IRAS ID
281530
Contact name
Philip James
Contact email
Sponsor organisation
Cardiff Metropolitan University
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
This study will look at the predictive nature of small cellular packages, classed as extracellular vesicles (EV), in the progression of stroke. EVs are highly involved in normal homeostasis, however, their number has been shown to increase in a number of diseased states. EV production has been closely linked with both cardiovascular disease and ischaemic events both in vitro and in vivo. Within the terms of this study, we will investigate EVs in stroke patients. We aim to determine changes to EV production, size, number, EV surface expression markers and content, following an ischaemic episode. Furthering changes to EV characteristics, we will determine if EVs play a role mechanistically in blood clot formation and in the progression of inflammation.
EV will be isolated from Transient Ischaemic Attack (TIA) patient blood samples. TIA patients have an increased risk (25%) of suffering a stroke within the following 12 months. We therefore hypothesize that changes to the EV population following an ischaemic event increase clotting potential and thus increase the risk of stroke in this cohort. TIA patients will be followed up over the following 12 month period, with those whom do suffer a stroke being re-sampled. The comparative group in this case will be those TIA patients whom don’t suffer with a stroke in the following 12 months and thus will be followed up as a control.REC name
West Midlands - Solihull Research Ethics Committee
REC reference
21/WM/0044
Date of REC Opinion
30 Mar 2021
REC opinion
Further Information Favourable Opinion