Extracellular vesicle function in Ischemic Heart Disease
Research type
Research Study
Full title
Investigation of extracellular vesicle function in patients with ischemic heart disease
IRAS ID
269313
Contact name
Keith Allen-Redpath
Contact email
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Ischemic heart disease (IHD) occurs when the arteries of the heart cannot provide an adequate supply of oxygen-rich blood to the heart. It is one of the leading causes of deaths relating to cardiovascular disease (CVD) worldwide. Despite major advances in understanding the disease, further research is required to answer outstanding questions. Extracellular vesicles (EVs) are small particles released from the surfaces of various cell types during activation, damage or cell death. They are present in the plasma of healthy subjects, but are increased in other health conditions and may be helpful in identifying CVD. However, techniques used to study EVs to date have had limitations and there is little information on what is contained within them and its role in CVDs. We propose to apply novel techniques developed in our lab to investigate the number, origin and composition of EVs in patients with IHD compared with healthy controls. The project will allow a unique opportunity to compare the EVs from arterial and venous blood; arterial blood is most relevant to the study of markers for IHD, but is technically difficult and has never been used for EV analysis. We will identify lipids within the EVs from both arterial and venous blood and use this novel information to understand the differences between EVs from healthy subjects vs. IHD patients, which could help identify a new marker for IHD.
REC name
North West - Haydock Research Ethics Committee
REC reference
20/NW/0263
Date of REC Opinion
19 Jun 2020
REC opinion
Further Information Favourable Opinion