Expression of m.3243 A>G

• Research type

  Research Study

• Full title

  Factors determining disease expression in mitochondrial disease due to the m.3243 A.G mutation

• IRAS ID

  182002

• Contact name

  Robert McFarland

• Contact email

  robert.mcfarland@ncl.ac.uk

• Sponsor organisation

  The Newcastle upon Tyne Hospitals NHS Foundation Trust

• Duration of Study in the UK

  1 years, 0 months, 1 days

• Research summary

  This study looks to investigate the role of mitochondrial dysfunction in the cause of stroke-like episodes (SLE). We hope by understanding this the findings may serve as a therapeutic target to prevent and/or delay the onset and development of SLE. This research may also be helpful in understanding the role of defective energy metabolism and changes to blood flow to the brain in more common disorders such as migraine and vascular stroke.

• REC name

  North East - Newcastle & North Tyneside 2 Research Ethics Committee

• REC reference

  15/NE/0399

• Date of REC Opinion

  23 Dec 2015

• REC opinion

  Favourable Opinion