Exploring visual pigment kinetics in AMD pathology
Research type
Research Study
Full title
Functional imaging of the outer retina using high fidelity imaging densitometry: exploring the relationship between visual pigment kinetics and AMD pathology
IRAS ID
289303
Contact name
Krishna Pattni
Contact email
Sponsor organisation
Cardiff University
Duration of Study in the UK
1 years, 5 months, 1 days
Research summary
The aim of this study is to develop a better understanding of the features seen in age-related macular degeneration (AMD) (such as fatty deposits known as drusen and reticular pseudodrusen) and their effect on the functioning of the outer retina (the light detecting layer at the back of the eye). This will be achieved by using a technique known as imaging retinal densitometry (a specialised camera) to provide a direct, objective assessment of the functioning of the central part of the retina (i.e. the macula) in order to answer the following questions:
1. What is the effect of drusen size on visual pigment (light absorbing molecules which mediate vision) regeneration rates?
2. Are rod (a type of light detecting cell in the retina) visual pigment synthesis rates preferentially impaired overlying reticular pseudodrusen, and likewise are cone (a type of light detecting cell in the retina) visual pigment synthesis rates preferentially impaired overlying soft drusen?
3. Are visual pigment synthesis rates affected in areas of ellipsoid zone (one of the retinal layers) disruption or loss?REC name
London - Surrey Research Ethics Committee
REC reference
21/PR/1553
Date of REC Opinion
19 Jan 2022
REC opinion
Further Information Favourable Opinion