Exploring somatic mutations in human tissue
Research type
Research Study
Full title
Exploring somatic mutations in human tissue to further understanding of the development of cancer
IRAS ID
363050
Contact name
Michael Stratton
Contact email
Sponsor organisation
Wellcome Sanger Institute
Duration of Study in the UK
10 years, 0 months, 0 days
Research summary
Cancer develops when changes in our DNA, called somatic mutations, build up in cells over time. Many are harmless, but some can drive cancer. Studying these changes in both healthy and diseased tissues can help explain why cancer arises, why rates differ across countries, and why some cancers are now more common in younger people.
This study will examine the number and types of DNA mutations in normal and cancerous tissues, focusing on cancers of the gastrointestinal and urinary systems. Samples will come from children and adults of different ages and from populations worldwide. By comparing these groups, we aim to understand why some tissues are more vulnerable to mutations and why cancer patterns vary between regions and age ranges.
Using DNA sequencing, we will look for “mutational signatures” – patterns of DNA change that reveal how and when mutations occur. The project is expected to run for about 10 years and will provide important insights into the processes that cause cancer and may inform future prevention strategies.
Only existing samples will be used. These include tissue, blood, urine, and stool collected by international collaborators under their own ethical approvals. All material will be anonymised before transfer to the Sanger. No new samples will be taken, and no personal information will be received by the research team.
REC name
West of Scotland REC 4
REC reference
25/WS/0154
Date of REC Opinion
2 Oct 2025
REC opinion
Favourable Opinion