Exploring disease mechanisms of endometriosis
Research type
Research Study
Full title
Identifying disease-promoting macrophages and tissue-identity signals in endometriosis
IRAS ID
263100
Contact name
Erin Greaves
Contact email
Sponsor organisation
University of Warwick
Duration of Study in the UK
4 years, 11 months, 30 days
Research summary
Endometriosis affects approximately 176 million women worldwide and is associated with debilitating pelvic pain and/or infertility. Endometriosis is defined by the presence of tissue similar to womb lining (endometrium) outside the womb (lesions), most commonly on the wall of the pelvic cavity. Endometriosis is currently treated surgically or with drugs that suppress sex hormones. However, symptoms often recur after surgery and available medical treatments have undesirable side-effects and are contraceptive. New treatments for endometriosis are desperately needed.
Endometriosis is primarily an inflammatory disorder exhibiting a large degree of symptom and disease presentation.
The aims of this study are
1. To unravel the degree of disease diversity by evaluating the gene expression profile of single cells in different types of endometriosis lesion
2. To identify cells that exhibit disease-modified characteristics
3. To identify new targets representing potential biomarkers or therapeutic interventionREC name
London - Surrey Borders Research Ethics Committee
REC reference
19/LO/1647
Date of REC Opinion
26 Nov 2019
REC opinion
Further Information Favourable Opinion