Exploring differences in NETosis in systemic lupus erythematosus (SLE)
Research type
Research Study
Full title
Exploring differences in NETosis in systemic lupus erythematosus (SLE)
IRAS ID
234264
Contact name
Ian Bruce
Contact email
Sponsor organisation
University of Manchester
Duration of Study in the UK
4 years, 0 months, 0 days
Research summary
SLE (or “lupus”) is an autoimmune disorder in which the over-active immune system attacks healthy tissue. It has recently been found that a particular type of immune cell called a neutrophil may be important in lupus (and related diseases).
This study aims to understand more about how the neutrophils of SLE patients behave. We want to study these cells in the lab to understand more about how they interact with other immune cells. In particular we are interested in a type of cell activity that may be specific to neutrophils (called NETosis). To do this study we will principally take blood samples from patients with lupus, other related diseases and from healthy volunteers.
Once we better understand how these cells behave we want to find out whether their behaviour is related to the type of disease people have or the medication they are taking. To do this we will look at some of the laboratory data and compare it to clinical disease features (including routine clinic blood tests and medication). We will also try to identify new drugs which affect how neutrophils behave in the lab.
Patients will primarily be recruited from Central Manchester University Hospitals. The study will last 4 years and participants may be asked to provide more than 1 blood sample over that time period.
REC name
London - London Bridge Research Ethics Committee
REC reference
18/LO/0236
Date of REC Opinion
18 Mar 2018
REC opinion
Further Information Favourable Opinion