Exploring Connectivity and Hidden Outcomes in Multiple Sclerosis 1.0
Research type
Research Study
Full title
Beyond the Surface: Investigating Brain Connectivity and Hidden Symptoms in Multiple Sclerosis
IRAS ID
347669
Contact name
Mara Cercignani
Contact email
Sponsor organisation
Cardiff University
Duration of Study in the UK
1 years, 7 months, 6 days
Research summary
Multiple sclerosis (MS) is a condition that can cause a range of symptoms, from physical disabilities to less visible issues like fatigue and cognitive difficulties. These "hidden" symptoms can be particularly challenging for people with MS because they are not always apparent to others. While we do not fully understand why these symptoms occur, we know they involve complex networks in the brain.
In this project, we are focusing on how MS affects the brain's communication pathways. MS damages parts of the brain responsible for sending messages, which could lead to problems like fatigue and depression. By studying the microstructure of the brain's white matter – specifically, the size of its pathways (axons) and the thickness of their protective coating (myelin) – we aim to understand how these changes relate to delays in brain signals.
We will work with 30 people who have relapsing-remitting MS and 30 healthy controls, using advanced imaging techniques like MRI and magnetoencephalography (MEG). We will also use standardized measures to assess arm/hand functioning, leg functioning/ambulation, cognitive function, fatigue and depression. By combining data from these scans and assessments, we hope to uncover how changes in the brain's structure contribute to the experience of hidden symptoms in MS.
Ultimately, our goal is to shine a light on the connections between brain damage in MS and the less obvious challenges patients face. By understanding these connections better, we can develop more effective ways to manage the symptoms that impact the daily lives of MS patients.REC name
London - Stanmore Research Ethics Committee
REC reference
24/PR/1384
Date of REC Opinion
16 Jan 2025
REC opinion
Further Information Favourable Opinion