Exhaled Breath Condenate in Bronchiectasis

• Research type

  Research Study

• Full title

  Exhaled Breath Condensate in Bronchiectasis- a novel non invasive method to assess microbial load in the airways

• IRAS ID

  165745

• Contact name

  Adam Hill

• Contact email

  adam.hill318@nhs.net

• Duration of Study in the UK

  1 years, 11 months, 31 days

• Research summary

  We will explore the bacterial yield using different methodologies of obtaining sputum in bronchiectasis. The methodologies we will compare include: induced sputum using salty water; spontaneous sputum; cough plate; exhaled breath condensate.

  Patients will be recruited from the bronchiectasis clinic. Following informed consent, patients will be brought back to the bronchiectasis dedicated room in the Royal Infirmary of Edinburgh and undergo the above tests.
  The tests will take less than 1 hour and requires a single visit only.

  All the methodologies are non invasive apart from induced sputum which is only mildly invasive. Induced sputum is used in routine clinical practice and is used to treat patients in hospital to aid sputum expectoration and patients with cystic fibrosis. The only minor risk is the airways narrowing following the procedure and if this develops patients will be given an inhaled medication which will reverse the airways narrowing.

• REC name

  London - South East Research Ethics Committee

• REC reference

  14/LO/2293

• Date of REC Opinion

  24 Dec 2014

• REC opinion

  Further Information Favourable Opinion