EXERT PCI study
Research type
Research Study
Full title
Assessment of exercise capacity and exercise coronary flow velocity pre and post percutaneous coronary intervention
IRAS ID
213758
Contact name
Justin Davies
Contact email
Sponsor organisation
Imperial College London and Imperial College Healthcare NHS Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Coronary stenting (also known as angioplasty or percutaneous coronary intervention - PCI) is a recommended treatment for patients with angina (symptoms of chest pain/shortness of breath) and evidence of coronary narrowings (also called stenoses). Almost all patients with angina report a worsening of their symptoms when they are exercising (e.g. when climbing the stairs/walking uphill). Despite the well known link between exercise and angina, almost all coronary stenting procedures are performed with patients lying completely still and thus completely at rest. We therefore do not have a good understanding of the effects of exercise on blood flow in the coronary circulation. We also do not have an understanding of the immediate effect of stenting on coronary blood flow or exercise capacity.
We therefore propose a prospective physiological study to assess the effect of coronary stenting on exercise capacity and coronary haemodynamic parameters (flow, pressure and resistance). Patients will be invited to perform exercise on a specially designed bicycle during their routine coronary stenting procedure. They will exercise on 2 occasions - once before their stent and once after their stent. This will allow us to compare the time they exercised before becoming fatigued, and see if stenting helps improve exercise capacity. We will also measure coronary flow in the following situations: a) at rest; b) during simulated exercise using a medicine called adenosine (this is standard clinical practice); and c) during real exercise. This will provide further valuable scientific data on the differences between realworld physiological exercise and simulated exercise using medicines.
REC name
London - Central Research Ethics Committee
REC reference
16/LO/1928
Date of REC Opinion
9 Nov 2016
REC opinion
Further Information Favourable Opinion