Exercise Therapy for Patients Listed for Liver Transplantation V-1.0
Research type
Research Study
Full title
Impact of exercise therapy on functional capacity in patients listed for liver transplantation - prospective, single-centre feasibility study
IRAS ID
221430
Contact name
Felicity Williams
Contact email
Sponsor organisation
University Hospitals Birmingham
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Patients with liver cirrhosis lose muscle mass as their disease progresses. This can lead to a decline in their level of function. Low levels of function and loss of muscle mass can lead to further complications such as a build-up of fluid, confusion and infection. Furthermore, patients with lower level of function are at higher risk of mortality and a longer stay in hospital pre-and post-liver transplantation. Exercise programmes can improve level of function, quality of life as well as prolong life in chronic disease. However, to date, there is limited data on the effect, safety and feasibility of exercise therapy on the functional capacity of patients on the liver transplant waiting list. \n\nThe aim of our study is to see if a 12-week home based exercise therapy program is feasible and will improve functional outcomes in patients listed for a liver transplantation. The results will be used to assess the need and guide the design of a large randomised-control trial of the impact of exercise therapy on functional capacity and its effects on pre-and post liver transplantation clinical outcomes.
REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
17/NW/0120
Date of REC Opinion
17 Mar 2017
REC opinion
Further Information Favourable Opinion