Exercise Prescribed at Different Levels of Claudication Pain
Research type
Research Study
Full title
The Effects of Exercise Prescribed at Different Levels of Intermittent Claudication Pain on Functional Outcomes in Patients with Intermittent Claudication
IRAS ID
283436
Contact name
Stefan Birkett
Contact email
Sponsor organisation
Lancashire Teaching Hospitals NHS Foundation Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Peripheral artery disease (PAD) affects over 236 million people globally. A classic symptom of PAD is intermittent claudication (IC), which is characterised by leg pain. IC is associated with various conditions such as diabetes, high blood pressure and high cholesterol as well as reductions in physical activity, quality of life, and balance. Strong evidence shows that supervised exercise programmes (SEP) improve pain free and maximal waking distance. However, adherence rates are poor with exercise-related pain shown as factor. Exercise at mild claudication or pain- free exercise improves walking ability, however current guidelines recommend exercise should be performed to near maximal claudication to improve walking ability. Conflicting evidence exists and there is a lack of evidence that has directly compared the effects of exercise prescribed at different levels of claudication as highlighted by the American Heart Association. Therefore, the primary objective is to directly compare the effects of exercise prescribed at different levels of claudication pain on functional outcomes
REC name
North West - Preston Research Ethics Committee
REC reference
20/NW/0401
Date of REC Opinion
10 Dec 2020
REC opinion
Further Information Favourable Opinion