Exercise Capacity Study - Part 2
Research type
Research Study
Full title
Exercise Capacity Study - Part 2
IRAS ID
234129
Contact name
Dana Dawson
Contact email
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
Research Summary
Cardiopulmonary exercise testing (CPEX) is increasingly being used in the clinical setting by various specialties because of the comprehensive wealth of data that can be acquired with a single test. It is a non-invasive and dynamic test that looks at a individual's performance at maximal exercise, and can provide valuable information about the cardiovascular, respiratory and metabolic status of an individual under physical stress.
We hope to use the data collected from this study to establish a range of reference values for studies that are currently being conducted by the University of Aberdeen and the Aberdeen Royal Infirmary which looks at CPEX testing in patients with cardiac conditions.Summary of Results
In the treated hypertensive patients blood pressure control was better in men (not significantly different from healthy controls) than women (significantly higher than controls). Their resting electrocardiograms were normal and echocardiography showed no differences in any of the parameters measured including global longitudinal strain. Their resting, peak exercise and 15-minute post-exercise BNP values were similar to those in the age and gender-matched controls.
In the Heart Failure with preserved Ejection Fraction patients the blood pressure was similar to healthy controls for both sexes and their resting electrocardiograms were also normal. Compared to controls there was a significantly lower VO2Peak, VO2 at anaerobic threshold, and OUES at peak exercise and higher VE/VC02 slope in both sexes as shown in Table 4 (men) and Table 5 (women). Their resting, peak exercise and 15-minute post-exercise BNP values were similar to those in age and sex matched healthy controls.
In patients with adult congenital heart defects the blood pressure was comparable to the age-matched healthy volunteers for both sexes. The resting electrocardiograms were abnormal for the majority of the patients with adult congenital heart disease in concordance with the underlying cardiac pathology. There were significant differences in multiple CPET variables.
VO2Peak values achieved in each of the patient groups were significantly lower when matched for age and sex compared to healthy participants (HT P=0.006, ACHD patients P<0.001 and HFpEF patients P<0.001).
In all 4 groups there was a good correlation between absolute VO2Peak and the OUES at maximal exercise at a RER of ≥1.05 (healthy volunteers r = 0.910, P<0.001, HT r = 0.899, P<0.001, ACHD r = 0.816, P<0.001 and HFpEF r = 0.846, P<0.001). Correlations were less strong for absolute VO2Peak vs OUES at a RER of 0.9 (healthy volunteers r =0.74, P<0.001, HT r =0.780, P<0.001, ACHD r = 0.651, P<0.001 and HFpEF r = 0.817, P<0.001). Correlations between absolute VO2Peak vs the OUES at maximal exercise and at a RER of 0.9 were significantly different only for healthy controls (P=0.001, Z-score = -4.649), but not for HT (P=0.05, Z-score = -1.909), ACHD (P=0.04, Z-score = -2.080) or HFpEF (P=0.7, Z-score = -0.377) patients.
REC name
North of Scotland Research Ethics Committee 1
REC reference
17/NS/0100
Date of REC Opinion
10 Oct 2017
REC opinion
Further Information Favourable Opinion