Exercise Ability in Children with Obliterative Bronchiolitis version 1
Research type
Research Study
Full title
The Functional Capacity of Children with Post-Infectious Obliterative Bronchiolitis
IRAS ID
158471
Contact name
Nuala Harnett
Contact email
Sponsor organisation
Newcastle upon Tyne Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 6 months, 0 days
Research summary
What is The Exercise Capacity of Children with Post-Infectious Obliterative Bronchiolitis?
Post Infectious Obliterative Bronchiolitis(PIOB) is a rare form of lung disease, often caused by a virus in early childhood. Symptoms include wheeze, shortness of breath, cough and recurrent chest infections. Treatment consists mainly of antibiotics and physiotherapy. Low oxygen levels and subjective limitations in exercise tolerance have been reported but there is little work done in this area. It is important to know how affected this group of children are and which exercise tests are most suitable to assess this.
Children aged 8 years and over with a diagnosis of PIOB will be eligible to participate. They will attend the Great North Children’s Hospital on 3 occasions, each visit lasting approximately 1 hour. Details including date of birth, sex, height, weight, oxygen saturations, lung function, use of oxygen and of a ventilator will be recorded. Following this they will be asked to do some in depth lung function tests. They will then complete two questionnaires. The first is called the Physical Activity Questionnaire and the second is a short questionnaire examining perceptions of their fitness levels compared to their peers.
At each of the second and third visits, they will take part in an exercise test. The first one is the modified shuttle test and is a field test involving walking/running at increasing speeds over a 10 metre course. The second test is on a treadmill and involves walking/running as the speed and incline of the treadmill increase. Heart rate and oxygen saturations will be measured throughout. Breathing rate and a breathlessness score will be recorded at the beginning and end of the tests. The amount of oxygen used will be measured during the treadmill test.
Breathtakers Charity for OB are funding an oxygen saturation monitor and travel expenses.
REC name
East Midlands - Nottingham 1 Research Ethics Committee
REC reference
15/EM/0046
Date of REC Opinion
16 Feb 2015
REC opinion
Further Information Favourable Opinion