Examining Hormones in Pilonidal Disease
Research type
Research Study
Full title
Examining Hormones in Pilonidal Disease
IRAS ID
298339
Contact name
Asha Senapati
Contact email
Sponsor organisation
London North West University Hospital NHS Trust
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
Pilonidal disease (PD) is a common disorder that occurs in the natal cleft (area between the buttocks). It has an incidence of around 26 per 100,000, and it is more than twice as common in men than women. Pilonidal disease rarely presents in patients who are prepubescent. In the current literature there are a lack of studies examining the relationship between hormone levels and pilonidal disease, despite the well-known physical and biochemical changes of hormones during puberty. Only one previous study by Ozkan et al (2013) has measured hormone status in patients with pilonidal disease. This small study concluded that the serum hormone prolactin was found to be raised in women with pilonidal disease. Other diseases thought to be linked to pilonidal disease, such as hidradenitis suppurativa (a disease which causes small painful lumps to form under the skin) also develop after puberty and are linked to abnormal rise of hormones in the body.
The purpose of this study is to establish whether there is any abnormal hormone level in patients with pilonidal disease, especially in hormones known to promote excess hair growth and changes in sweat gland function.
REC name
Yorkshire & The Humber - Sheffield Research Ethics Committee
REC reference
22/YH/0147
Date of REC Opinion
8 Jul 2022
REC opinion
Favourable Opinion