Examining endogenous antioxidants in well trained cyclists
Research type
Research Study
Full title
The effects of habitual antioxidant supplementation on endogenous antioxidants and oxidative stress in well trained cyclists
IRAS ID
125663
Contact name
Sarah Aldred
Contact email
Sponsor organisation
University of Birmingham
Research summary
We will establish a local cohort study of 5200 participants. In consenting participants we will extract data from health records on NHS number, disorders, symptoms, surgical procedures, medications, adverse drug reactions and pathology records and we will collect a saliva DNA sample. We will link information from the health care record to information on genetic variations from the DNA sample. The genetic associations we will study in the cohort will provide insights to inform the prevention, diagnosis and treatment of illnesses such as chronic obstructive pulmonary disease, asthma, kidney disease, diabetes, cardiovascular disease, cancers, joint problems and of combinations of different diseases (multiple morbidity). The utility of the study will not be restricted to the study of genetic associations – for example, it will be possible to investigate the influence of smoking or alcohol intake on multiple morbidity. We will invite participants from the study to take part in further studies, specifically “recruit by genotype” studies and “recruit by phenotype” studies. A “recruit by genotype” study allows us to study in detail the effects of specific naturally occurring variants in genes. First we will identify genetic variations in the DNA samples of participants, and then we will invite small numbers of participants based on this information. For example, we would invite a small group of participants carrying a particular genetic variant, and a comparison group who do not carry the genetic variant. A “recruit by phenotype” study could allow us to study causes of a particular disease, for example by inviting some participants who have chronic obstructive pulmonary disease (COPD) and a comparison group who do not have the disease.
REC name
West Midlands - Solihull Research Ethics Committee
REC reference
13/WM/0226
Date of REC Opinion
29 Jul 2013
REC opinion
Further Information Favourable Opinion