Exacerbation of Adjacent Segment Disease due to PILL Mismatch, Ver.6
Research type
Research Study
Full title
Exacerbation of Adjacent Segment Disease due to Mismatch of Pelvic incidence and Lumbar Lordosis after Lumbar Spinal Fusion
IRAS ID
253311
Contact name
Santosh Baliga
Contact email
Duration of Study in the UK
0 years, 7 months, 1 days
Research summary
The aging population has put the importance of spinal health maintenance into the spotlight. Due to the wear and tear of the spinal column, the spine and the associated spinal muscles could degenerate gradually. Over time, the biomechanics of the spine could deviate from the optimal position and may require additional muscular input to sustain a normal posture. Eventually, the musculature can no longer compensate with the additional strain, leading to a myriad of debilitating symptoms.
While conservative treatments are usually offered as the first-line treatment, lumbar spinal fusion has demonstrated to be highly effective in restoring lumbar spinal stability and eliminating other associated symptoms of spinal degeneration. However, recent studies have shown that alteration of spinal mechanics through lumbar spinal fusion could promote the manifestation of adjacent segment disease (ASD), the degeneration of adjacent segments of the original offending vertebrae.
Patients with ASD often suffer from symptoms that are similar to the symptoms that prompted the first fusion surgery, including lower back pain and spinal instability. Although conservative symptomatic treatments are available, these patients often have to undergo further invasive surgeries to repair the deteriorated segments.
Recently, two measurable parameters relating to the position of the pelvis and the spinal curvature have been used to determine the risk of developing ASD in lumbar spinal fusion patients. Such parameters are also associated to the risk of future revision surgeries. This study aims to investigate whether these parameters can also be used in monitoring the progression of ASD in lumbar spinal fusion patients.REC name
East of Scotland Research Ethics Service REC 2
REC reference
19/ES/0059
Date of REC Opinion
8 Jul 2019
REC opinion
Further Information Favourable Opinion