Ex Vivo Heart Perfusion Study
Research type
Research Study
Full title
Evaluation of Hypothermic Oxygenated Perfusion (HOP) Ex-Vivo Heart Perfusion to Expand the Donor Pool and Improve Transplant Outcomes
IRAS ID
253506
Contact name
John Dark
Contact email
Sponsor organisation
The Newcastle upon Tyne Hospitals NHS Foundation Trust
Clinicaltrials.gov Identifier
BH149192, Reference Number
Duration of Study in the UK
1 years, 11 months, 31 days
Research summary
Many hearts kindly offered for transplant are not used routinely as there is concern about how well they may work following a difficult transplant operation. The purpose of the project is to improve our understanding of the impact of machine perfusion, at low temperature, but with blood containing oxygen, a method which mimics the natural blood supplied from a beating heart to itself, on heart health, in comparison with presently utilised cold preservation in an ice bath. We hope to be able to:
• Extend the acceptable duration of heart preservation prior to transplant
• Develop tests so that we can better assess heart health and quality prior to transplantation
• Extend these investigations to hearts donated after circulatory death, a field in which the UK leads the world, but which currently depends on prohibitively expenive American technologyIn addition, the hearts clinically being transplanted under the current practice will be recruited as control group. We will take samples from and assess these hearts before and after transplantation, and compare the results against those from the hearts, which are perfused by the machine, in the research group.
The results of this research will be used to improve safety while also reducing the amount of time patients spend on 'waiting lists' prior to transplantation.
REC name
North East - Newcastle & North Tyneside 1 Research Ethics Committee
REC reference
19/NE/0132
Date of REC Opinion
24 May 2019
REC opinion
Favourable Opinion