Ex-BodyComp-Hb study Version 1
Research type
Research Study
Full title
Longitudinal investigation of changes in body composition, inflammatory markers and haematological responses to erythropoietin hormone before and after exercise intervention among haemodialysis patients
IRAS ID
229786
Contact name
Helena Jackson
Contact email
Sponsor organisation
St George's, University of London and St George's University Hospitals NHS Foundation Trust
Duration of Study in the UK
0 years, 9 months, 31 days
Research summary
The cause of anaemia among end stage kidney disease patients is multifactorial, and their response to management therapies varies. How much muscle and fat someone has may be important although it is unclear which component (lean tissue, fat tissue and/or fat distribution) most influences anaemia. Different exercise interventions have been shown to improve body composition and heart health, make dialysis more effective and reduce inflammation among dialysis patients. Previous exercise studies in patients on dialysis have used exercise bikes. We wish to trial a more practical, flexible and affordable form of aerobic exercise (i.e walking) and to combine this with resistance training and to investigate the effect of this on patients’ iron status, body composition, inflammation, cardiac health, functional capacity and dialysis effectiveness. If the exercise interventions can promote beneficial changes in body composition and these are shown to influence health outcomes this will inform the management of these dialysis patients. The study will involve adult (≥18yrs) chronic kidney disease patients who have been on haemodialysis maintenance therapy for at least 3 months, have a haemoglobin concentration of ≤120g/l and would have already started or are to start anaemia management therapies (iron and/or erythropoietin hormone). This study has two stages; Stage 1 is set to observe changes over time on specific components of body composition (lean tissue, fat tissue and/or fat distribution), markers of inflammation and those of iron metabolism to investigate the relationship between them. In stage 2, a practical and flexible aerobic exercise (walking) together with resistance training will be introduced and investigate their effect on specific components of body composition, inflammatory markers and the subsequent modification effect on anaemia status. The study will also investigate the impact of this exercise approach on heart rate variability, functional capacity and quality of life in this group of dialysis patients.
REC name
London - Queen Square Research Ethics Committee
REC reference
18/LO/0443
Date of REC Opinion
1 May 2018
REC opinion
Further Information Favourable Opinion