EVEREST - IBD
Research type
Research Study
Full title
EVEREST-IBD: Endoscopic severity image recognition to advance research and training in Inflammatory Bowel Disease
IRAS ID
299614
Contact name
Shaji Sebastian
Contact email
Sponsor organisation
Hull University Teaching Hospitals NHS Trust
Duration of Study in the UK
3 years, 0 months, 30 days
Research summary
Crohn's Disease (CD) and Ulcerative Colitis (UC) are chronic inflammatory bowel diseases (IBD) of unknown aetiology. IBD care is complex, and variation in diagnostic pathways, care patterns and outcomes is common, numerous studies show significant variation in IBD management across all clinical care settings. Endoscopy is a cornerstone of IBD management. Endoscopy is utilized to identify inflammation including its pattern, location and to differentiate inflammation from non-inflammatory pathology, such as dysplasia. Endoscopic assessment also plays an integral part in disease exacerbation management and cancer surveillance.
Endoscopic scoring systems in IBD provide objectively, uniformity and standardization with reporting of mucosal appearances, augmenting clinical decision making and ultimately having an impact on appropriate treatment targets and desirable patient outcomes. Real-world endoscopic reporting is, however, limited by inconsistent use of standardized scoring systems, imprecision, and variation in reporting, through significant interpretative element.
Currently endoscopic practice depends on the ability of the operator to detect and interpret abnormal images produced from light reflected off gastrointestinal tract mucosal surfaces. Endoscopic assessments are naturally operator-dependent with high inter-observer variability. The study will collect a large number of endoscopic images both prospectively and retrospectively to produce high impact research outcomes and training resources leading to an improvement in the quality of endoscopy performed, reduce inter-observer variability in disease assessment and a reduction in missed bowel cancer rates and associated mortality.REC name
Yorkshire & The Humber - Leeds East Research Ethics Committee
REC reference
21/YH/0110
Date of REC Opinion
10 Jul 2021
REC opinion
Further Information Favourable Opinion