Evaluation of Tomographic 3D US for the Assessment of Vascular disease
Research type
Research Study
Full title
The Evaluation of Tomographic 3D Ultrasound for the Assessment of Vascular Pathology.
IRAS ID
280010
Contact name
ADEL ALZAHRANI
Contact email
Sponsor organisation
Imperial College London and Imperial College Healthcare NHS Trust
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 7 months, 1 days
Research summary
Currently, evaluating vascular disease within arterial and venous systems (stenosis, Patency, and Competency) using Duplex ultrasound relays on a B-mode (Brightness mode) and Colour Doppler mode. The criteria currently used are the measurement of blood flow velocity (PSV) and also the ratio of the velocity (PSVR) in case of grading the degree of stenosis in arterial system assessment. Arterial wall thickness which is known as Intima-Media Thickness (IMT) measurement is also used to determine whether or not that particular vessel is building a plaque in between its layers.
Small changes within the plaque cannot be noticed using current routine IMT measurements. Therefore, 3D tomographic ultrasound Plaque volume measurement may provide better visualisation and gives more details if the plaque has any changes within its size and shape. 3D Plaque volume will be measured and correlated with current criteria (PSV and PSVR) to find out whether it does provide more accurate results than current criteria being used or not. 3D Ultrasound may also provide more accurate images for assessing veins for the use of surgical bypass than routine Doppler ultrasound.
In the assessment of arteriovenous fistula (AVF), 3D ultrasound may provide better diagnostic images and evaluation in measuring the degree of stenosis. It may give better results about the stenotic area and its total luminal reduction parentage and therefore help the vascular surgeon to better treatment plan and surgical outcomes.REC name
London - Surrey Research Ethics Committee
REC reference
20/LO/0814
Date of REC Opinion
9 Nov 2020
REC opinion
Further Information Favourable Opinion