Evaluation of nonlinear propagation artifact correction
Research type
Research Study
Full title
Evaluation of nonlinear propagation artifact correction
IRAS ID
163478
Contact name
Adrian Lim
Contact email
Sponsor organisation
Imperial College NHS Healthcare Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
A wide range of major diseases manifest themselves through changes in blood flow and tissue perfusion. Contrast enhanced ultrasound (CEUS) is a promising tool in imaging blood flow and tissue perfusion and has potential in diagnosing and monitoring diseases such as coronary artery diseases, cancer, liver diseases, peripheral vascular diseases and carotid atherosclerosis. Such diseases could be diagnosed or monitored by studying the microcirculation. However, ultrasound contrast agents also cause image artifacts where tissue regions deep to contrast-filled vessels appear as bright as the vessels themselves making it difficult to distinguish between tissue and vessel regions. We have developed a method to reduce this artifact and wish to conduct a more detailed study using a real patient population and to determine the actual clinical effectiveness of the method. The method promises to improve qualitative and quantitative assessment of microcirculation which could make significant impact in translating CEUS to a wider range of clinical applications.
REC name
North West - Greater Manchester East Research Ethics Committee
REC reference
15/NW/0276
Date of REC Opinion
14 May 2015
REC opinion
Further Information Favourable Opinion