Evaluation of monocyte subset markers in CABG patients
Research type
Research Study
Full title
Evaluation of monocyte subset markers in coronary artery bypass graft patients
IRAS ID
319739
Contact name
Jason Johnson
Contact email
Sponsor organisation
University of Bristol
Duration of Study in the UK
0 years, 8 months, 1 days
Research summary
The main objective of this exploratory study is to determine if we can identify a subset of cells within an individual’s circulating blood that could be used to identify their susceptibility to an adverse outcome after cardiac surgery, such as another heart attack. White blood cells known as monocytes are associated with the occurrence of adverse events after coronary artery bypass-graft surgery (CABG), but within an individual’s circulating blood monocytes can exist in different forms (subsets) considered good and bad. We will therefore identify and quantify the numbers of bad monocytes alongside the proteins and packages of molecules (exosomes) they release to determine if they predict outcomes after CABG surgery. Specifically, this will include major adverse cardiovascular events such as heart attack, stroke, or cardiovascular death. To address this question, we aim to analyse samples and clinical data from patients who have undergone CABG, compared to those who have undergone other cardiac procedures which are not associated with major adverse coronary artery-related events.
REC name
London - London Bridge Research Ethics Committee
REC reference
22/PR/1590
Date of REC Opinion
7 Dec 2022
REC opinion
Favourable Opinion