Evaluation of lymph nodes and surgical margin in breast cancer surgery
Research type
Research Study
Full title
Evaluation of lymph nodes and surgical margin in breast cancer surgery using Fast Raman spectroscopy analysis
IRAS ID
264699
Contact name
Ioan Notingher
Contact email
Sponsor organisation
University of Nottingham
Clinicaltrials.gov Identifier
00000, 00000
Duration of Study in the UK
3 years, 0 months, 1 days
Research summary
Breast cancer is the most prevalent cancer among women, in case of invasive breast cancer, SLN biopsy is a rapidly emerging treatment option for patients with early-stage and a clinically negative axilla. Breast conservative surgery is currently the most widely used surgical procedure for resection of breast cancer. The aim is to remove the entire tumour while leaving healthy breast tissue intact, providing better cosmetic outcome as well as remove the sentinel lymph nodes where the cancer cell have migrated to in order to reduce the need for re-admission of patients with positive SLN. Postoperatively, the excises tissue are examined histologically to determine if the breast surgery has been successful and if additional lymph nodes needs to be removed. This process typically takes 1–2 weeks, and in more than 20% of BCS procedures, positive margins are detected (i.e. tumor close to the edge) and additional operations are required to achieve complete excision . Nearly half of these “re-excisions” are for “on-ink” margins, meaning that tumor was found on the surface of the excised tissue.
This is an early stage proof of concept study to test whether the Fast Raman technique can assess the margins of breast wide local excisions compatible with intra-operative timescales and perform biopsy of sentinel lymph nodes.
REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
19/EM/0251
Date of REC Opinion
11 Sep 2019
REC opinion
Further Information Favourable Opinion