Evaluation of imaging biomarkers in cardiovascular medicine
Research type
Research Study
Full title
Evaluation of imaging biomarkers in cardiovascular medicine
IRAS ID
208017
Contact name
Phil Chowienczyk
Contact email
Sponsor organisation
Kings College London
Duration of Study in the UK
2 years, 11 months, 31 days
Research summary
Cardiovascular function is evaluated by examining images of the heart. However, relatively few numerical measures of the complex mechanical function of the heart, particularly its coupling to the arteries are used to determine treatment strategies. The purpose of the present study is to examine a range of quantitative indices of cardiovascular function that can be derived from modern imaging coupled to simple non-invasive measures of arterial function. Patients with a range of primarily cardiac conditions (valve disease and heart muscle disease) and arterial conditions (hypertension, aortic disease and peripheral vascular disease) will be studied. The value of existing and novel indices of cardiovascular function in predicting outcomes, response to treatment, and their link to biological markers of cardiovascular function will be evaluated. In a sub-sample of participants indices will be measured before and after an intervention that transiently alters cardiovascular function.
REC name
London - Queen Square Research Ethics Committee
REC reference
18/LO/1424
Date of REC Opinion
5 Oct 2018
REC opinion
Favourable Opinion