Evaluation of antimicrobial prophylaxis after Manchester Arena bombing
Research type
Research Study
Full title
Evaluation of the effectiveness of antimicrobial prophylaxis guidance at preventing wound infection following bomb blast in Manchester, England.
IRAS ID
239948
Contact name
Marc Handford
Contact email
Sponsor organisation
Public Health England
Duration of Study in the UK
0 years, 6 months, 1 days
Research summary
Following the Manchester Arena bombing on 22nd May 2017 there was rapidly drafted antimicrobial prophylaxis guidance put in place to prevent wound infection in those injured. There is limited literature regarding which antibiotics are best used in such situations so the policy was largely based on expert opinion.
The aim of this study is to assess the effectiveness of the antimicrobial prophylaxis guidance at preventing wound infection in those injured in the bomb-blast.
The study design is a retrospective cohort study. We will include all people injured in the Manchester Arena bombing. Data will be collected via three streams:
1. Clinical notes from the eight Greater Manchester Hospital Trusts who initially treated the bomb blast victims will be reviewed to determine the nature of their injuries and whether they were prescribed prophylactic antibiotics.
2. Questionnaires will be sent to the GPs of those injured by the bomb blast. The relevant GP practices are spread across the UK. We will ask GPs to review their clinical notes for evidence of wound infection. GPs will be compensated for their time for completing the questionnaire as it falls outside of their NHS contract. Compensation at rate of £48.40 per questionnaire.
3. For those patients with documented wound infection we will review PHE Second Generation Surveillance System (SGSS) database to look for information regarding causative organism.
We will analyse the data collected to answer the primary outcome question, "What were the rates of secondary wound infection in patients who received antibiotic prophylaxis compliant with antimicrobial policy". We will also look various other secondary outcome measures including levels of adherence to the antimicrobial policy and rates of associated clostridium difficile infection.
All data will be stored centrally on a secure database.
The results of this study will be complied into a report for publication and use in updating national guidance as required.
REC name
East Midlands - Leicester South Research Ethics Committee
REC reference
18/EM/0100
Date of REC Opinion
7 Dec 2018
REC opinion
Further Information Favourable Opinion