EURO-ICE
Research type
Research Study
Full title
SELECTIVE INTRACORONARY HYPOTHERMIA IN PATIENTS WITH ST-ELEVATION MYOCARDIAL INFARCTION TO REDUCE INFARCT SIZE
IRAS ID
248267
Contact name
Richard Good
Contact email
Sponsor organisation
Catharina Hospital, Eindhoven
Clinicaltrials.gov Identifier
Duration of Study in the UK
1 years, 0 months, 1 days
Research summary
In acute heart attack, early restoration of blood flow to the heart muscle is of paramount importance to limit the infarction size and create optimum conditions for favourable long-term outcome. Currently, restoration of heart muscle blood flow is preferably and effectively obtained by using a balloon to dilate and open the blocked artery and place a scaffold called a stent (Primary Percutatneous Coronary Intervention or 'PPCI') After opening the blocked artery, however, the reperfusion or restoration of blood flow process itself, causes damage to the myocardium, the so called "reperfusion injury". The phenomenon of reperfusion injury is incompletely understood and currently there is no established therapy for preventing it. Contributory factors are intramyocardial oedema with compression of the microvasculature, oxidative stress, calcium overload, mitochondrial transition pore opening, micro embolisation, neutrophil plugging and hyper contracture. This results in myocardial stunning, reperfusion arrhythmias and ongoing myocardial necrosis and damage. There is general agreement that a large part of the cell death caused by myocardial reperfusion injury occurs during the first few minutes of reperfusion, and that early treatment is required to prevent it.
This study aims to evaluate the effectiveness of selective heart artery hypothermia (cooling) in patients with large heart attacks to limit reperfusion injury and to limit infarct (heart attack) size.
Therefore, this proof-of-principle study in humans, is the subject of this protocol.REC name
West of Scotland REC 4
REC reference
18/WS/0223
Date of REC Opinion
22 Jan 2019
REC opinion
Further Information Favourable Opinion