Eulerian Video Magnification in the Assessment of Peripheral Perfusion

  • Research type

    Research Study

  • Full title

    Eulerian Video Magnification in the Assessment of Peripheral Perfusion



  • Contact name

    Colin W Primrose

  • Contact email

  • Sponsor organisation

    NHS GG&C Research and Development

  • Duration of Study in the UK

    1 years, 0 months, 4 days

  • Research summary

    Funded by the British Society of Interventional Radiology, this proof of concept study aims to explore a novel video-based approach to assess peripheral perfusion in individuals with peripheral arterial disease (PAD). PAD is a common condition in the UK, characterised by symptoms such as pain, tissue loss, and related complications. Current imaging techniques for assessing PAD are costly, inaccessible, and involve ionising radiation, limiting their widespread use in patient selection and treatment evaluation.

    The study specifically focuses on investigating the potential of Eulerian Video Magnification (EVM), a video processing technique, to assess skin perfusion in the lower limbs. Skin perfusion, indicating blood flow in the skin, serves as an important indicator of tissue health and overall circulation. Implementing EVM for video-based perfusion assessment could greatly enhance patient evaluation in primary care, peri-procedural care, and vascular clinics.

    To validate EVM's effectiveness, we will compare its results with those obtained from laser Doppler flowmetry (LDF), an experimental perfusion assessment method. Initially, this comparison will involve healthy volunteers – staff members at the Queen Elizabeth University Hospital (QEUH) in Glasgow. Subsequently, the assessments will be repeated on QEUH patients selected for angioplasty, a procedure that restores blood flow to the lower limb by inflating a balloon in the arteries. We will obtain data using EVM and LDF before and after the procedure, as well as during follow-up clinic visits several weeks later. Importantly, our study methods are purely observational (video and laser probes) and do not involve radiation exposure, even though angioplasty itself exposes patients to ionising radiation. This study will have no impact on patient management or patient flow.

    Over the course of 12 months, our goal is to recruit 20-30 healthy volunteers and 20-30 QEUH patients to participate in this study.

  • REC name

    North West - Haydock Research Ethics Committee

  • REC reference


  • Date of REC Opinion

    4 Mar 2024

  • REC opinion

    Further Information Favourable Opinion