ESSEX - SAAMI
Research type
Research Study
Full title
The Essex Stable Angina and Acute Myocardial Infarction study. Combining invasive coronary pressure and temperature-derived guidewire physiological assessments with novel angiography-based physiological assessment tools to characterise acute and chronic and coronary syndrome states.
IRAS ID
306187
Contact name
Thomas Keeble
Contact email
Sponsor organisation
Mid and South Essex NHS Hospitals Trust
Duration of Study in the UK
12 years, 0 months, 5 days
Research summary
Coronary artery disease is common and can lead to symptoms of chronic exertional chest pain and shortness of breath, as well as heart attacks. These conditions are caused by either narrowing of the arteries, or complete blockages. As part of treatment for these conditions, patients may undergo a coronary angiogram procedure to take pictures of the arteries, as well as a stenting procedure to relieve the narrowing or blockage. Despite this, a significant proportion of patients will continue to experience symptoms. In heart attacks, sometimes relieving the blockage does not result in adequate blood flow through the artery.
These issues are thought to be contributed to by the coronary microvascular circulation. These are the small blood vessels downstream of the main arteries. They are not visible on coronary angiography and are not usually investigated during angiography and stenting procedures. They are also too small to have stents. The coronary microvascular circulation is an area of growing interest however diagnosis and treatment of coronary microvascular dysfunction is an area of unmet clinical need.
This study aims to investigate the effects of chronic coronary syndrome(CCS) and acute coronary syndromes(ACS) on coronary flow and resistance using pressure and temperature sensitive wires. It also aims to develop novel and less invasive methods of investigating these factors using computer based software. In turn, we aim to develop methods of assessing patients' microvascular circulation using computer software so that their care be improved in the future.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
22/EE/0016
Date of REC Opinion
7 Mar 2022
REC opinion
Further Information Favourable Opinion