ESPRESSO
Research type
Research Study
Full title
Early Supported discharge with Pulmonary REhabilitation following Severe acute exacerbations of COPD – Safety and Outcomes (ESPRESSO)
IRAS ID
269894
Contact name
William Man
Contact email
Sponsor organisation
Royal Brompton and Harefield NHS Foundation Trust
Duration of Study in the UK
2 years, 0 months, 1 days
Research summary
We would like to find out if it is possible to combine a supervised home-based exercise programme with a service which provides medical care for patients in their own homes (known as early supported discharge or hospital at home) after they have been in hospital with a flare-up of chronic obstructive pulmonary disease (COPD). We also would like to find out if patients, family members/carers and healthcare professionals involved in this research feel combining the home-based exercise programme within an early supported discharge service is acceptable.
This is important as pulmonary rehabilitation ((PR): an outpatient-based exercise and education programme delivered by healthcare professionals from different clinical backgrounds) increases the distance a patient can walk and quality of life, and reduces the risk of patients going back into hospital. However very few patients attend outpatient-based PR after a flare-up. One of the reasons for this is because patients find it hard to travel to the outpatient classes after being in hospital.
We will recruit 80 patients who have been admitted to hospital with a flare-up of COPD. We will randomly allocate half of the patients to receive a home-based exercise programme alongside usual early supported discharge care, with the other half receiving usual early supported discharge care alone. The patients recruited will be assessed before being discharged from hospital. The assessment will include measures of quality of life, activity levels, muscle strength, anxiety and depression, exercise capacity and body composition. These will be re-assessed 4 weeks and 3 months after being discharged. Safety outcomes will be recorded 3 months and 12 months after the patients have been discharged from hospital.
We will talk to patients, family members/carers and healthcare professionals involved in this study to explore their views of the combined intervention after the 3 month assessments have finished.
REC name
London - Dulwich Research Ethics Committee
REC reference
19/LO/1472
Date of REC Opinion
18 Sep 2019
REC opinion
Favourable Opinion