ESCAPE-imagING evaluation (ESCAPE-ING)
Research type
Research Study
Full title
Effect of Sulforaphane on Prostate CAncer PrEvention-imagING evaluation (ESCAPE-ING)
IRAS ID
155166
Contact name
Richard Mithen
Contact email
Research summary
We propose to undertake a pilot study on a group of men with early prostate cancer on active surveillance to determine whether a diet rich in broccoli will induce changes in tumor size and blood flow measured by conventional Magnetic Resonance Imaging (MRI) techniques. Men with early prostate cancer on active surveillance who have visible cancer lesions on MRI will be recruited onto this double-blinded randomized intervention and they will be asked to eat one portion of broccoli soup per week for 6 months. We will test two varieties of broccoli (standard and 'Beneforte extra' broccoli) that are able to deliver two different levels of sulforaphane (SF), an active compound extensively studied for its potential anticancer properties. This study will involve MRI scans, blood and urine collection before and after a 6 month intervention period. This study design will not only allow us to observe diet-induced changes within the prostate but also at the systemic level. In addition, participant's lifestyle (habitual diet and physical activity) will be assessed by food diaries and exercise questionnaires.
This proposed pilot study has a similar design to the ESCAPE study (REC ref number 13/EE/0110) that is currently running at the Institute of Food Research (IFR) in collaboration with the Norfolk and Norwich University Hospital (NNUH). We believe that both studies will provide valuable information on the association between diet and prostate cancer risk and will help to design future studies with a larger study population and clinical endpoints.REC name
East of England - Cambridge South Research Ethics Committee
REC reference
14/EE/1149
Date of REC Opinion
18 Nov 2014
REC opinion
Further Information Favourable Opinion