ESCAPE-CORE
Research type
Research Study
Full title
Longitudinal MR Imaging to characterise tissue damage patterns in acute Ischaemic stroke (ESCAPE-CORE)
IRAS ID
344577
Contact name
James Kennedy
Contact email
Sponsor organisation
University of Calgary
Clinicaltrials.gov Identifier
REB23-1813, Conjoint Health Research Ethics Board (CHREB), University of Calgary, Canada
Duration of Study in the UK
1 years, 3 months, 0 days
Research summary
The purpose of this international collaborative research study is to find out more about the different mechanisms in which brain tissue gets harmed by and recovers following acute ischaemic stroke. An ischaemic stroke is caused by blockage of a major blood vessel in the brain. This blockage causes a cascade of different ways in which the brain reacts to this, and MRI provides a safe method to characterise these events without use of radiation (as would be the case with CT scans). MRI is a routinely available method to image these different mechanisms of brain damage and healing that occur in ischaemic stroke.
It is hoped that if we can find and characterize different ways in which the brain gets harmed using MRI, we might be able to develop targeted medications to prevent these harmful mechanisms from happening, and that we can monitor the success of these treatments with MRI.
REC name
South Central - Hampshire A Research Ethics Committee
REC reference
25/SC/0354
Date of REC Opinion
6 Jan 2026
REC opinion
Further Information Favourable Opinion