Erythroderma Study
Research type
Research Study
Full title
Erythroderma: exploration of changes in metabolism, appetite, hydration status and body composition
IRAS ID
257172
Contact name
Simon Tso
Contact email
Sponsor organisation
University Hospitals Coventry and Warwickshire NHS Trust
Duration of Study in the UK
5 years, 0 months, 1 days
Research summary
The purpose is to perform the first proof-of-concept study exploring the effects of the Erythrodermic state on energy expenditure, hydration status and body composition. Erythroderma is one of the leading causes of skin failure. Comparison will be made of metabolic and body composition data during the patient's Erythrodermic state and at follow-up (following recovery from their Erythrodermic episode if this is an acute episode). Through this it will be possible for the first time to ascertain the metabolic burden associated with Erythroderma. This information will also be compared against published data of normal healthy subjects. Combined with assessments of appetite and caloric intake (based on measurements of appetite hormones, visual analogue assessments of appetite and self-reported food intake through use of food diaries), these data will provide insight into the dietary and nutritional requirements of patients with Erythroderma. This will be helpful as a means to mitigate against the associated weight-loss of this condition.
Potential participants can choose which part of the study they'd like to participate in. The first part is purely observational and involves the research team collecting clinical/metabolic/body composition data relevant to their Erythrodermic state that are generated through routine clinical care.
The second part includes up to two overnight stays at the Human Metabolism Research Unit at UHCW for energy expenditure measurement, body composition measurements, blood tests, questionnaires and keeping a food diary.
We will use the preliminary data generated from this pilot study, as a basis for a subsequent more substantive study on the metabolic and appetitive effects of Erythroderma. Our ultimate aim and purpose is to use published evidence-based data generated from our metabolic studies on Erythroderma, as a sound basis for the development of novel and much-needed guidelines for the effective metabolic management of Erythroderma, particularly regarding dietary and nutritional requirements.
REC name
East of England - Cambridgeshire and Hertfordshire Research Ethics Committee
REC reference
21/EE/0222
Date of REC Opinion
24 Aug 2021
REC opinion
Favourable Opinion