ERIC-QOL
Research type
Research Study
Full title
Quantification of radiation-induced neuro-cognitive dysfunction, anxiety, and Quality of Life (QoL) in patients with high grade gliomas
IRAS ID
300115
Contact name
Pinelopi Gkogkou
Contact email
Sponsor organisation
Norfolk and Norwich University Hospitals NHS Foundation Trust
Duration of Study in the UK
1 years, 0 months, 0 days
Research summary
Side effects caused by radiotherapy (RT) for high grade gliomas can significantly affect cognitive function which could minimise the quality of life (QoL) and increase anxiety of patients. Loss of cognition causes significant decrease in quality of life and anxiety in patients receiving radiotherapy and chemotherapy for high grade gliomas. Symptoms depend on what level of cognition is lost and include impaired attention and memory, and inability to concentrate. These deficits negatively affect patients’ well-being and increase anxiety levels. Therefore, quantifying QoL and mood disturbances of the patients with high-grade gliomas has become a significant aspect of their management.
This study aims to identify whether there is any safe threshold dose to avoid cognitive dysfunction of neuroanatomical structures (hippocampus, corpus callosum and sub-ventricular system of lateral ventricles) and define how quality of life is affected and how it is correlated with the cognitive dysfunction.REC name
West Midlands - Black Country Research Ethics Committee
REC reference
21/WM/0163
Date of REC Opinion
22 Jul 2021
REC opinion
Further Information Favourable Opinion