EPORVA V1
Research type
Research Study
Full title
Electrophysiological Phenotyping Of patients at Risk of Ventricular Arrhythmia and sudden cardiac death
IRAS ID
255939
Contact name
Fu Siong Ng
Contact email
Sponsor organisation
Imperial College London
ISRCTN Number
ISRCTN00000000
Clinicaltrials.gov Identifier
Duration of Study in the UK
2 years, 7 months, 31 days
Research summary
Heart rhythm problems, also called arrhythmia, are very common in the population. We know that some long term (chronic) medical problems, for example, obesity, diabetes, arthritis and various forms of heart disease, increase the risk of arrhythmia. Despite this, we do not fully understand why or how arrhythmia develop in these common medical problems. We wish to investigate how common chronic medical conditions, like obesity, and genetic differences can change the electrical activity of the heart, and thereby increase the risk of arrhythmia. Our ability to study arrhythmia has been limited to 12-lead electrical recordings of the heart (ECG). Our research will use more sophisticated 252-lead ECGs and heart scans to provide more detailed information about the heart’s electrical activity to achieve two aims. Firstly, to study the electrical activity of the heart in individuals who may have a higher risk of arrhythmia. Secondly, to understand if existing treatment for some chronic medical conditions can reduce the risk of arrhythmia. In so doing, we hope to develop a better understanding of why some people have a higher risk of arrhythmia and what can be done to predict, prevent and treat it. We hope that this research will help to inform future clinical guidelines and improve future treatment of arrhythmia. Participants in the study will involve those with chronic medical problems, for example obesity and heart disease, and will be conducted at the hospitals associated with Imperial College London. We anticipate that the study will last about 30 months.
REC name
London - Surrey Research Ethics Committee
REC reference
19/LO/0762
Date of REC Opinion
25 Jun 2019
REC opinion
Further Information Favourable Opinion