Epigenetics of musculoskeletal disease

• Research type

  Research Study

• Full title

  Genetic and epigenetic analysis of joint disease

• IRAS ID

  255976

• Contact name

  John Loughlin

• Contact email

  john.loughlin@ncl.ac.uk

• Sponsor organisation

  Newcastle Hospitals NHS Foundation Trust

• Duration of Study in the UK

  3 years, 9 months, 31 days

• Research summary

  Overview
  The MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing (CIMA) is a unique team.
  CIMA brings in a mix of skills from three major U.K. Universities: Liverpool, Newcastle and Sheffield. It helps doctors and lab scientists to work together to grasp:
  1) How our muscles, bones and joints change as we age.
  2) How this makes some people prone to problems with these tissues such as arthritis and osteoporosis.
  3) What each person can do to reduce the risk of developing these problems.

  Specifically, we will; determine how epigenetic changes in the ageing musculoskeletal system influence the risk of musculoskeletal disorders, the effect of modification of epigenetic changes on musculoskeletal function, and the effect of lifestyle changes on epigenetic marks and molecules

• REC name

  London - Harrow Research Ethics Committee

• REC reference

  19/LO/0389

• Date of REC Opinion

  5 Jul 2019

• REC opinion

  Further Information Favourable Opinion