EPIC: Effect on ePcs by the Implantation of Cardiac closure devices

• Research type

  Research Study

• Full title

  The effect on Endothelial progenitor cells (EPCs) by successful cardiac closure device implantation

• IRAS ID

  200090

• Contact name

  Robert Butler

• Contact email

  rob.butler@uhns.nhs.uk

• Sponsor organisation

  University Hospitals of North Midlands NHS Trust

• Duration of Study in the UK

  0 years, 6 months, 30 days

• Research summary

  All patients awaiting to have either a left atrial appendage closure (LAA) or patent foramen ovale (PFO) closure device as part of standard care will be identified and reviewed in cardiology clinics. These patients will be placed on waiting list to undergo the procedure. Patient-participants will be consented on the date of admission for device closure implantation.
  The study will recruit 20 patients divided into; 10 patients undergoing PFO closure and 10 patients undergoing LAA closure. EPC will be measured on the day of the device implantation, day 0 and prior to discharge on day 1. Patient-participants are admitted overnight after the device closure implantation. Then on subsequent out patient cardiology research clinic follow appointments on days (3-4) and (7-8).

• REC name

  East Midlands - Leicester South Research Ethics Committee

• REC reference

  16/EM/0242

• Date of REC Opinion

  24 Jun 2016

• REC opinion

  Favourable Opinion