Epi-SICCS
Research type
Research Study
Full title
Epigenetic susceptibility to inflammatory complications after cardiac surgery (Epi-SICCS)
IRAS ID
362096
Contact name
Benjamin Shelley
Contact email
Sponsor organisation
National Waiting Times Centre Board
Duration of Study in the UK
1 years, 6 months, 0 days
Research summary
This single-centre observational study at The Golden Jubilee National Hospital aims to understand 3 key questions in patients undergoing major heart surgery:
1. Why do some patients experience worse complications than others?
2. Are there markers on our genetic makeup (called epigenetic modifications) that can predict complications?
3. How do epigenetic modifications trigger excessive inflammation that causes complications?Major surgery is associated with increased risk of complications, which are a leading cause of death, delayed recovery, long-term illness and increased healthcare cost. In response to surgery, an inflammatory response is triggered as part of a complex repair mechanism, however, in some cases inflammation can become exaggerated, leading to complications.
We believe that excessive inflammation after surgery is influenced by a system of markers on DNA; a scientific field known as epigenetics. Where a patient’s DNA (their ‘genetics’) may be considered as an instruction manual for each cell’s functions, these ‘epigenetic’ markers work as if someone has highlighted sections of the manual to be read (and actioned). The pattern of epigenetic markers on immune system cells can therefore dictate the extent of the inflammatory response, especially after an insult such as major surgery. While DNA cannot be easily modified, epigenetic markers can be modified, through available strategies including diet, exercise, and medication.
We will:
1. Obtain blood samples before and after surgery to test for epigenetic markers and inflammation.
2. Collect routine data from laboratory tests and patient observations to assess for complications and inflammation.
3. Conduct patient questionnaires before and after surgery.
4. Identify patients with complications after surgery and analyse their epigenetic markers and subsequent inflammatory response.With this knowledge, future studies could trial personalised treatment strategies before surgery, to modify the epigenetic makeup and reduce harm from complications. We are not testing any new treatments in this study.
REC name
London - South East Research Ethics Committee
REC reference
26/LO/0117
Date of REC Opinion
5 Mar 2026
REC opinion
Further Information Favourable Opinion