Eosinophilic oesophagitis (EoE): A study
Research type
Research Study
Full title
Eosinophilic oesophagitis (EoE): A study of biomarkers and disease triggers in adults
IRAS ID
266357
Contact name
Emma Perry
Contact email
Sponsor organisation
UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST
Clinicaltrials.gov Identifier
N/A, N/A
Duration of Study in the UK
3 years, 11 months, 2 days
Research summary
The aim of this educational project (PhD) is to study biomarkers associated with Eosinophilic Esophagitis (EoE), a newly discovered chronic immune-mediated oesophageal condition, using a Coiled Oesophageal String Test (CEST) to collect oesophageal fluid. An ELISA assay will test IgG4 oesophageal fluid collected from adult patients samples attending EoE clinics. The research is interested to check: if IgG present in the oesophageal fluid is linked to reflux or EoE, associations of Ig4 with food triggers/ seasonal changes and how Eosinophil Cationic Protein (ECP) can monitor disease activity and general EoE Biomarkers. The project will be conducted at the University Hospital Southampton (UHS) Immunology department and reviewed (only anonymised patient data) by Portsmouth University. The research project will be run between 09/2019 and 09/2023. The study has the potential to eliminate the need for invasive diagnostic procedures (e.g. endoscopies, biopsies), reduce diagnostic costs, expand the knowledge regarding treatment and management of EoE and to help to find strategies to improve the well being of patients suffering from this condition.
REC name
West Midlands - South Birmingham Research Ethics Committee
REC reference
19/WM/0346
Date of REC Opinion
5 May 2020
REC opinion
Further Information Favourable Opinion