EON-Lung: Effect Of Nitrate levels in Lung Disease.

  • Research type

    Research Study

  • Full title

    EON-Lung: Effect Of Nitrate levels in Lung Disease - an observational study.



  • Contact name

    Nicholas Hopkinson

  • Contact email


  • Sponsor organisation

    Imperial College London

  • Duration of Study in the UK

    2 years, 8 months, 1 days

  • Research summary

    Background: Despite optimum medical treatment many patients with lung disease remain significantly disabled. There is evidence that dietary nitrate supplementation, in the form of beetroot juice concentrate, can reduce the oxygen cost of exercise and have other beneficial effects on blood vessels but it is not clear if this improves exercise capacity.
    The purpose of this project is to investigate whether there is a link between blood levels of nitrate and nitrite and the severity of disease severity. We also want to see if a measure of exhaled nitric oxide, commonly used to track airway inflammation, can also be used to identify people with low blood nitrate levels.
    Study Design: A single centre, observational study. 100 patients will be studied. Patients with lung disease who agree to take part will have blood taken for nitrate and nitrite levels, exhaled nitric oxide measured, a mouth swab to collect oral bacteria (which influence the way that the body metabolises nitrate). These will be compared to measures of breathlessness and other respiratory symptoms as well as blood pressure, lung function and smoking history.
    Expected outcome: There is a need for novel strategies to improve exercise capacity in people with lung disease. As a relatively cheap, nondrug intervention beetroot juice has the potential to be widely applicable. Data from this study will help in the design of future trials to test this.

  • REC name

    East of England - Cambridge Central Research Ethics Committee

  • REC reference


  • Date of REC Opinion

    28 Nov 2019

  • REC opinion

    Further Information Favourable Opinion

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