Entropy-based Physiological signal analysis in Patients with OSA v1
Research type
Research Study
Full title
Entropy-Based Assessment of Physiological Signals in Obstructive Sleep Apnoea Patients Pre and Post Continuous Positive Airway Pressure Therapy: A Secondary Analysis of 3DPiPPIn Trial Data
IRAS ID
366646
Contact name
Ime O Umoabasi
Contact email
Sponsor organisation
King's College London
Clinicaltrials.gov Identifier
NCT07406620, National Clinical Trial (NCT) ID Number
Duration of Study in the UK
0 years, 5 months, 3 days
Research summary
Purpose
Obstructive Sleep Apnoea (OSA) is a common sleep condition in which breathing repeatedly stops and starts during sleep. In the UK, it affects 1.5 million people. The best treatment for OSA is a breathing machine that delivers Continuous Positive Airway Pressure (CPAP) through a face mask worn during sleep.This research will assess how the body responds to CPAP by studying patterns in body measurements related to breathing, oxygen levels in the blood, and heart rate. A mathematical approach called entropy will be used to describe how regular or complex these body measurements are over time.
Why is this study needed?
While we know that CPAP works well, we also know that people can respond to it in different ways. Despite this, the clinical measure commonly used to show that CPAP is working provides little to no information about how the body adapts to treatment, and instead focuses exclusively on reporting whether breathing disturbances during sleep are reduced. We think this research could help improve understanding of how CPAP affects different body systems and support the development of better ways of monitoring how well treatment is working in people with OSA.
What will be done in this study?
This is a secondary analysis, meaning it will use data that have already been collected from up to 160 adults who took part in an earlier study called 3DPiPPIn (ISRCTN74082423). No one will be newly recruited or newly assessed for this study.Patterns in body measurements recorded before CPAP treatment will be compared with those recorded after three and six months of treatment. We will also explore whether changes in these patterns are related to changes in the number of breathing disturbances during sleep and self-reported levels of daytime sleepiness.
This research is sponsored by King's College London and is unfunded.
REC name
London - Bloomsbury Research Ethics Committee
REC reference
26/PR/0369
Date of REC Opinion
10 Apr 2026
REC opinion
Favourable Opinion