Enhancing European Management of Analgesia, Sedation and Delirium

• Research type

  Research Study

• Full title

  Enhancing European Management of Analgesia, Sedation and Delirium - Implementation and Validity of Pain, Agitation and Delirium Screening in the ICU – an International, Prospective Multicentre Observational Trial

• IRAS ID

  248716

• Contact name

  James Hanison

• Contact email

  james.hanison@mft.nhs.uk

• Sponsor organisation

  Charité-Universitätsmedizin Berlin

• Duration of Study in the UK

  1 years, 0 months, 1 days

• Research summary

  This prospective, multicentre study aims to evaluate the effect of routine training of intensive care unit (ICU) staff on the implementation rate of screening tools for pain, agitation and delirium (PAD). The evaluation will take the form of one day point-prevalence analysis, administered both pre- and post-training phase. ICU-staff will be trained in PAD screening and management in accordance with international guidelines. The initial point-prevalence analysis will take place preceding the training phase. Two additional analyses are set to occur 6 weeks and 12 months after the training program has ended (i.e. three point-prevalence analyses in total). The training package contains online lectures, instructional videos, educational handouts, and a bedside teaching component over the course of 6 weeks. The training package is not experimental, but is well-established nationally in Germany.
  Primary hypothesis: A training algorithm published by Radtke et al. will lead to an improved implementation rate of routine delirium screening (using validated tools, e.g. CAM-ICU, NuDESC) 6 weeks after the training phase has concluded.
  Secondary hypotheses: The prevalence of delirium screening in routine clinical practice is lower than assumed by ICU staff. In cases of routine implementation, the delirium screening tools (e.g. CAM-ICU) detect delirium less reliably than would be extrapolated from study data on their diagnostic performance. Primary clinical endpoint: • Rate of delirium screening (Prevalence) during the course of a 3-shift weekday as documented in the patient chart. *Radtke FM, Heymann A, Franck M, et al. How to implement monitoring tools for sedation, pain and delirium in the intensive care unit: an experimental cohort study. Intensive Care Med 2012.

• REC name

  London - Bromley Research Ethics Committee

• REC reference

  18/LO/1796

• Date of REC Opinion

  30 Nov 2018

• REC opinion

  Further Information Favourable Opinion