Energy metabolism and MRS
Research type
Research Study
Full title
Brain energy metabolism measured by magnetic resonance spectroscopy: Pilot Studies in chronic fatigue syndrome and bipolar disorder
IRAS ID
180785
Contact name
Philip Cowen
Contact email
Sponsor organisation
University of Oxford
Duration of Study in the UK
1 years, 10 months, 31 days
Research summary
The aim of the research is to carry out a pilot study of a new method of measuring energy production in the brain in two clinical conditions that have been linked to faulty energy production- bipolar disorder and chronic fatigue syndrome. The measurement of energy production will be carried out using magnetic resonance spectroscopy (MRS) which employs a powerful magnet to identify biochemical changes in the brain in a non-invasive way. We will use brief exposure to a flashing light to stimulate energy production in the visual part of the brain and see if energy production differs in patients with bipolar disorder and CFS compared to controls. A positive result would lead onto larger studies to confirm the findings and eventually new avenues for improving diagnosis and treatment of these conditions. The work will take place in the University of Oxford at the John Radcliffe Hospital and is funded by the University Department of Psychiatry.
REC name
South Central - Oxford A Research Ethics Committee
REC reference
15/SC/0373
Date of REC Opinion
24 Jul 2015
REC opinion
Further Information Favourable Opinion