Endsocopic Radiofrequency Ablation for Inlet patch
Research type
Research Study
Full title
ENDOSCOPIC RADIOFREQUENCY ABLATION FOR TREATMENT OF SYMPTOMATIC CERVICAL INLET PATCH - FEASABILITY STUDY
IRAS ID
136167
Contact name
Terry Wong
Contact email
Sponsor organisation
Guy's & St Thomas' NHS Foundation Trust
Research summary
Inlet patch is a congenital anomaly of the cervical esophagus consisting of heterotopic gastric mucosa. Its prevalence varies from 0.1% - 10% in endoscopic studies.The cervical inlet patch is often associated with symptoms including globus pharyngeus (feeling of ball in back of throat), mucus, cough and pain. Fundic gland mucosa is the most common histologic type - Oxyntic glands with parietal cells and chief cells, leading to acid secretion. Cardia type mucosa is often found which are mucus secreting glands. Treatment with acid supression medications is often partially successful as it does not treat mucus. A previous study of ablation of these small areas using argon plasma coagulation showed symptomatic response in 82%. The technique is technically challenging and there is wide variation in the energy delivery and hence depth of ablation. Radiofrequency ablation using the BarrX device has been shown to be safe and effective for ablation of oesophgeal mucosa (Barrett's oesophagus, squamous dysplasia). The device is CE marked for approval of ablation throughout the GI tract. This study will evalaute the device for ablation of cervical inlet patch.
REC name
London - London Bridge Research Ethics Committee
REC reference
13/LO/1386
Date of REC Opinion
20 Nov 2013
REC opinion
Further Information Favourable Opinion