Endothelial cell activation in Idiopathic pneumonitis syndrome
Research type
Research Study
Full title
Role of endothelial cell damage and activation in idiopathic pneumonia syndrome post stem cell transplantation
IRAS ID
260246
Contact name
Andrew R Gennery
Contact email
Clinicaltrials.gov Identifier
6996, Caldicott
Duration of Study in the UK
1 years, 11 months, 0 days
Research summary
Bone marrow transplantation is an important treatment for many congenital immune deficiencies and benign or malignant haematological diseases. A rare but important complication of the treatment, due to the process of transplantation, is damage to the internal lining of blood vessels which usually occurs in the first 3 months following transplantation. This can lead to liver, kidney, lung and other organ damage. There is an effective treatment for this complication, which is most effective when started early. Unfortunately, it is not possible to predict which patients will develop this complication.
We will take blood during routine accessing of the central line, once a week for 14 weeks, and store it. If the patient develops the complication, we will analyse the stored blood for chemicals associated with damage of the blood vessel internal lining, to see if we can detect a chemical signature that predicts development of the complication. Any treatment that is required will be decided by the clinical team looking after the patient, and is not part of this study.
Additionally, we will re-examine historic biopsy specimens from deceased patients for evidence of blood vessel lining damage.
REC name
East of England - Cambridge South Research Ethics Committee
REC reference
19/EE/0320
Date of REC Opinion
2 Jan 2020
REC opinion
Further Information Favourable Opinion