Endothelial and plasma parameters in coagulation disorders

• Research type

  Research Study

• Full title

  Endothelial and plasma parameters in coagulation disorders – prospective observational study

• IRAS ID

  316809

• Contact name

  Deepa Jayakody Arachchillage

• Contact email

  d.arachchillage@imperial.ac.uk

• Sponsor organisation

  Imperial College London

• Duration of Study in the UK

  3 years, 0 months, 0 days

• Research summary

  Vascular disease is a major cause of morbidity and mortality. Vascular events typically result in the blocking of a blood vessel by thrombosis which may occur suddenly or after years of vessel damage. Impairment of the lining of blood vessels (endothelial dysfunction) leads to development of many forms of vascular disease. Lining of the healthy blood vessels (endothelium) maintains stable balance by providing an anti-clotting and anti-inflammatory surface and maintain the vascular tone by producing factors such as nitric oxide, a molecule that help the lumen of the blood vessel open state.
  Immunological diseases such as antiphospholipid syndrome (APS), systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) are well known to have impaired lining of the blood vessels (endothelial dysfunction )which is associated with an increased risk of blood clots including clots in the leg, lungs , stroke, and heart attacks
  Most studies of vascular disorders have concentrated on measurements of blood coagulation factors and most therapies have also been directed at blood components (eg anticoagulants and antiplatelet therapies). It is possible that some of the routine medications we use in patients with these diseases have undocumented effects on function of the lining of the blood vessels which are beneficial. It is also possible that therapies could be more effective and safer if they were directed towards modifying endothelial function. In this prospective observational study, we will combine measurements of blood and endothelial function as measured by non-invasive method using EndoPat, like checking oxygen level in the figure and the blood pressure measurement in the arm both at presentation and after therapy or observation. Follow up will allow us to correlate these with relevant clinical events (i.e new or recurrent blood clots, or bleeding events)

• REC name

  London - Brighton & Sussex Research Ethics Committee

• REC reference

  22/PR/1452

• Date of REC Opinion

  10 Jan 2023

• REC opinion

  Further Information Favourable Opinion