EndoAKI V1.0
Research type
Research Study
Full title
Vascular Endothelial Dysfunction in the Development of Acute Kidney Injury in Patients Undergoing Cardiac Surgery.
IRAS ID
227555
Contact name
Nishith Patel
Contact email
Sponsor organisation
Papworth Hospital NHS Foundation Trust
Duration of Study in the UK
4 years, 11 months, 27 days
Research summary
Kidney injury affects over a third of patients undergoing open heart surgery and it leads to an increased risk of further complications, prolonged hospital stay and increased hospital costs. Currently there are no preventative interventions, primarily because we do not have a clear understanding of the condition. Cells that line the inner surface of all our blood vessels, known as endothelial cells, may have an important role in the development of kidney injury as they are involved in controlling blood flow. Exposure to the heart lung machine, which is used in most heart operations, may damage these endothelial cells.
The aim of our research is to better understand the role of endothelial cells, which line the blood vessels in patients who develop kidney injury following heart surgery.
Using ultrasound and blood tests, we will study the changes that occur in endothelial cells in patients undergoing heart surgery.
Our research may improve the understanding of kidney injury following heart surgery.REC name
Wales REC 6
REC reference
17/WA/0167
Date of REC Opinion
8 Jun 2017
REC opinion
Favourable Opinion